8IVA

Cryo-EM structure of SARS-CoV-2 spike protein in complex with double nAbs XMA01 and 3E2 (local refinement)

Summary for 8IVA

• Entry DOI: 10.2210/pdb8iva/pdb
• EMDB information: 35755
• Descriptor: heavy chain of XMA01, light chain of XMA01, Spike protein S1, ... (6 entities in total)
• Functional Keywords: sars-cov-2, neutralizing antibody, cryo-em, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 5
• Total formula weight: 72643.84

Authors

Sun, H.,Jiang, Y.,Zheng, Q.,Li, S.,Xia, N. (deposition date: 2023-03-26, release date: 2023-08-16, Last modification date: 2024-02-14)

• Primary citation: Sun, H.,Deng, T.,Zhang, Y.,Lin, Y.,Jiang, Y.,Jiang, Y.,Huang, Y.,Song, S.,Cui, L.,Li, T.,Xiong, H.,Lan, M.,Liu, L.,Li, Y.,Fang, Q.,Yu, K.,Jiang, W.,Zhou, L.,Que, Y.,Zhang, T.,Yuan, Q.,Cheng, T.,Zhang, Z.,Yu, H.,Zhang, J.,Luo, W.,Li, S.,Zheng, Q.,Gu, Y.,Xia, N.; Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD.; Protein Cell, 15:121-134, 2024; PubMed: 37470320; DOI: 10.1093/procel/pwad040

Experimental method

ELECTRON MICROSCOPY (3.95 Å)