8ISM

HSA-Pt compound complex

8ISM の概要

• エントリーDOI: 10.2210/pdb8ism/pdb
• 分子名称: Serum albumin, PALMITIC ACID, 7-(2-azanyl-5-chloranyl-phenyl)-3$l^{3}-thia-5,6$l^{4}-diaza-2$l^{3}-platinatricyclo[6.4.0.0^{2,6}]dodeca-1(12),3,6,8,10-pentaen-4-amine (3 entities in total)
• 機能のキーワード: complex, metal binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 68252.26

構造登録者

Zhang, J.Z.,Zhang, Z.L. (登録日: 2023-03-21, 公開日: 2024-03-27, 最終更新日: 2025-08-20)

主引用文献

Zhang, Z.,Zhang, J.,Yang, T.,Li, S.,Xu, G.,Liang, H.,Yang, F.
Developing an Anticancer Platinum(II) Compound Based on the Uniqueness of Human Serum Albumin.
J.Med.Chem., 66:5669-5684, 2023

PubMed Abstract: To develop the next-generation Pt drug with remarkable activity and low toxicity to maximally inhibit tumor growth, we optimized a Pt(II) thiosemicarbazone compound (C4) with remarkable cytotoxicity to SK-N-MC cells and then constructed a new human serum albumin-C4 (HSA-C4) complex delivery system. The results showed that C4 and the HSA-C4 complex have remarkable therapeutic efficiency and almost no toxicity; they induced apoptosis and inhibited tumor angiogenesis. This system showed potential as a practical Pt drug. This study could pave the way for developing next-generation dual-targeted Pt drugs and achieving their targeting therapy for cancer.

PubMed: 37071741
DOI: 10.1021/acs.jmedchem.3c00001

実験手法

X-RAY DIFFRACTION (2.76 Å)