8IQX

ferritin mutant-P156H

8IQX の概要

• エントリーDOI: 10.2210/pdb8iqx/pdb
• 分子名称: Ferritin (2 entities in total)
• 機能のキーワード: asterias forbesii ferritin, mutant-p156h, metal binding protein
• 由来する生物種: Asterias forbesi (Forbes's starfish)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 155397.46

構造登録者

Zhao, G.,Zhang, C.,Zang, J.,Zhang, T. (登録日: 2023-03-17, 公開日: 2024-02-21)

主引用文献

Zhang, C.,Chen, X.,Liu, B.,Zang, J.,Zhang, T.,Zhao, G.
Preparation and Unique Three-Dimensional Self-Assembly Property of Starfish Ferritin.
Foods, 12:-, 2023

PubMed Abstract: The structure and assembly properties of ferritin derived from aquatic products remain to be explored. Constructing diverse three-dimensional (3D) protein architectures with the same building blocks has important implications for nutrient delivery, medicine and materials science. Herein, ferritin from (AfFer) was prepared, and its crystal structure was resolved at 1.91 Å for the first time. Notably, different from the crystal structure of other reported ferritin, AfFer exhibited a BCT lattice arrangement in its crystals. Bioinspired by the crystal structure of AfFer, we described an effective approach for manufacturing 3D porous, crystalline nanoarchitectures by redesigning the shared protein interface involved in different 3D protein arrays. Based on this strategy, two 3D superlattices of body-centered tetragonal and simple cubicwere constructed with ferritin molecules as the building blocks. This study provided a potentially generalizable strategy for constructing different 3D protein-based crystalline biomaterials with the same building blocks.

PubMed: 37959022
DOI: 10.3390/foods12213903

実験手法

X-RAY DIFFRACTION (2.5 Å)