8IOV

Structure of SARS-CoV-2 XBB.1 spike RBD in complex with ACE2

8IOV の概要

• エントリーDOI: 10.2210/pdb8iov/pdb
• EMDBエントリー: 35626
• 分子名称: Processed angiotensin-converting enzyme 2, Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: spike glycoprotein, viral protein, viral protein-protein binding complex, viral protein/protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 211570.95

構造登録者

Anraku, Y.,Kita, S.,Yajima, H.,Sasaki, J.,Sasaki-Tabata, K.,Maenaka, K.,Hashiguchi, T. (登録日: 2023-03-13, 公開日: 2023-05-24, 最終更新日: 2024-11-06)

主引用文献

Tamura, T.,Ito, J.,Uriu, K.,Zahradnik, J.,Kida, I.,Anraku, Y.,Nasser, H.,Shofa, M.,Oda, Y.,Lytras, S.,Nao, N.,Itakura, Y.,Deguchi, S.,Suzuki, R.,Wang, L.,Begum, M.M.,Kita, S.,Yajima, H.,Sasaki, J.,Sasaki-Tabata, K.,Shimizu, R.,Tsuda, M.,Kosugi, Y.,Fujita, S.,Pan, L.,Sauter, D.,Yoshimatsu, K.,Suzuki, S.,Asakura, H.,Nagashima, M.,Sadamasu, K.,Yoshimura, K.,Yamamoto, Y.,Nagamoto, T.,Schreiber, G.,Maenaka, K.,Hashiguchi, T.,Ikeda, T.,Fukuhara, T.,Saito, A.,Tanaka, S.,Matsuno, K.,Takayama, K.,Sato, K.
Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants.
Nat Commun, 14:2800-2800, 2023

PubMed Abstract: In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified, and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that XBB emerged through the recombination of two cocirculating BA.2 lineages, BJ.1 and BM.1.1.1 (a progeny of BA.2.75), during the summer of 2022. XBB.1 is the variant most profoundly resistant to BA.2/5 breakthrough infection sera to date and is more fusogenic than BA.2.75. The recombination breakpoint is located in the receptor-binding domain of spike, and each region of the recombinant spike confers immune evasion and increases fusogenicity. We further provide the structural basis for the interaction between XBB.1 spike and human ACE2. Finally, the intrinsic pathogenicity of XBB.1 in male hamsters is comparable to or even lower than that of BA.2.75. Our multiscale investigation provides evidence suggesting that XBB is the first observed SARS-CoV-2 variant to increase its fitness through recombination rather than substitutions.

PubMed: 37193706
DOI: 10.1038/s41467-023-38435-3

実験手法

ELECTRON MICROSCOPY (3.29 Å)