8IMW
Crystal structure of response regulator PmrA receiver domain
Summary for 8IMW
| Entry DOI | 10.2210/pdb8imw/pdb |
| Descriptor | Transcriptional regulator (2 entities in total) |
| Functional Keywords | polymyxin resistance, pmra, response regulator, receiver domain., dna binding protein |
| Biological source | Acinetobacter baumannii (strain ATCC 19606 / DSM 30007 / JCM 6841 / CCUG 19606 / CIP 70.34 / NBRC 109757 / NCIMB 12457 / NCTC 12156 / 81) |
| Total number of polymer chains | 2 |
| Total formula weight | 30855.57 |
| Authors | Ouyang, Z.,Wen, Y. (deposition date: 2023-03-07, release date: 2024-03-13, Last modification date: 2024-05-15) |
| Primary citation | Ouyang, Z.,He, W.,Jiao, M.,Yu, Q.,Guo, Y.,Refat, M.,Qin, Q.,Zhang, J.,Shi, Q.,Zheng, F.,Wen, Y. Mechanistic and biophysical characterization of polymyxin resistance response regulator PmrA in Acinetobacter baumannii. Front Microbiol, 15:1293990-1293990, 2024 Cited by PubMed Abstract: PmrAB is a crucial two-component regulatory system (TCS) that plays a vital role in conferring resistance to polymyxin. PmrA, a response regulator belonging to the OmpR/PhoB family, is composed of a C-terminal DNA-binding effector domain and an N-terminal receiver domain. The receiver domain can be phosphorylated by PmrB, a transmembrane sensor histidine kinase that interacts with PmrA. Once phosphorylated, PmrA undergoes a conformational change, resulting in the formation of a symmetric dimer in the receiver domain. This conformational change facilitates the recognition of promoter DNA by the DNA-binding domain of PmrA, leading to the activation of adaptive responses. PubMed: 38476937DOI: 10.3389/fmicb.2024.1293990 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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