8IM7

Human gamma-secretase treated with ganglioside GM1

Summary for 8IM7

• Entry DOI: 10.2210/pdb8im7/pdb
• EMDB information: 35572
• Descriptor: Nicastrin, Presenilin-1 CTF12, Gamma-secretase subunit APH-1A, ... (9 entities in total)
• Functional Keywords: intramembrane protease, lipid, ganglioside, gm1, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 178966.75

Authors

Zhou, R.,Yang, G.,Shi, Y. (deposition date: 2023-03-06, release date: 2024-01-17)

• Primary citation: Wang, X.,Zhou, R.,Sun, X.,Li, J.,Wang, J.,Yue, W.,Wang, L.,Liu, H.,Shi, Y.,Zhang, D.; Preferential Regulation of Gamma-Secretase-Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer's Disease.; Adv Sci, 10:e2303411-e2303411, 2023; PubMed: 37759382; DOI: 10.1002/advs.202303411

Experimental method

ELECTRON MICROSCOPY (3.4 Å)