8IM7

Human gamma-secretase treated with ganglioside GM1

8IM7 の概要

• エントリーDOI: 10.2210/pdb8im7/pdb
• EMDBエントリー: 35572
• 分子名称: Nicastrin, Presenilin-1 CTF12, Gamma-secretase subunit APH-1A, ... (9 entities in total)
• 機能のキーワード: intramembrane protease, lipid, ganglioside, gm1, membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 178966.75

構造登録者

Zhou, R.,Yang, G.,Shi, Y. (登録日: 2023-03-06, 公開日: 2024-01-17)

• 主引用文献: Wang, X.,Zhou, R.,Sun, X.,Li, J.,Wang, J.,Yue, W.,Wang, L.,Liu, H.,Shi, Y.,Zhang, D.; Preferential Regulation of Gamma-Secretase-Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer's Disease.; Adv Sci, 10:e2303411-e2303411, 2023; PubMed: 37759382; DOI: 10.1002/advs.202303411

実験手法

ELECTRON MICROSCOPY (3.4 Å)