8ILS

Cryo-EM structure of PI3Kalpha in complex with compound 17

8ILS の概要

• エントリーDOI: 10.2210/pdb8ils/pdb
• EMDBエントリー: 35545
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, N-[(2R)-1-(ethylamino)-1-oxidanylidene-3-[4-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide, ... (4 entities in total)
• 機能のキーワード: phosphoinositide 3-kinase, drug target, ligand, binding pocket, chemical scaffold, structural protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 211974.38

構造登録者

Zhou, Q.,Liu, X.,Neri, D.,Li, W.,Favalli, N.,Bassi, G.,Yang, S.,Yang, D.,Vogt, P.K.,Wang, M.-W. (登録日: 2023-03-04, 公開日: 2023-09-13)

• 主引用文献: Zhou, Q.,Liu, X.,Neri, D.,Li, W.,Favalli, N.,Bassi, G.,Yang, S.,Yang, D.,Vogt, P.K.,Wang, M.W.; Structural insights into the interaction of three Y-shaped ligands with PI3K alpha.; Proc.Natl.Acad.Sci.USA, 120:e2304071120-e2304071120, 2023; PubMed: 37585458; DOI: 10.1073/pnas.2304071120

実験手法

ELECTRON MICROSCOPY (3.1 Å)