8II3
Crystal structure of V30M-TTR in complex with 6-hydroxy BID
Summary for 8II3
Entry DOI | 10.2210/pdb8ii3/pdb |
Descriptor | Transthyretin, [3,5-bis(iodanyl)-4-oxidanyl-phenyl]-(2-ethyl-6-oxidanyl-1-benzofuran-3-yl)methanone (3 entities in total) |
Functional Keywords | thyroxine, amyloidosis, inhibitor, transport protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 35753.33 |
Authors | Yokoyama, T. (deposition date: 2023-02-24, release date: 2023-06-28, Last modification date: 2024-05-29) |
Primary citation | Mizuguchi, M.,Yokoyama, T.,Okada, T.,Nakagawa, Y.,Fujii, K.,Nabeshima, Y.,Toyooka, N. Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis. Bioorg.Med.Chem., 90:117370-117370, 2023 Cited by PubMed: 37311373DOI: 10.1016/j.bmc.2023.117370 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.399 Å) |
Structure validation
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