8IGB
Crystal structure of SARS-Cov-2 main protease P132H mutant in complex with GC376
Summary for 8IGB
Entry DOI | 10.2210/pdb8igb/pdb |
Descriptor | 3C-like proteinase nsp5, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide (3 entities in total) |
Functional Keywords | viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | Severe acute respiratory syndrome coronavirus 2 |
Total number of polymer chains | 2 |
Total formula weight | 67190.70 |
Authors | |
Primary citation | Lin, C.,Zhu, Z.,Jiang, H.,Zou, X.,Zeng, X.,Wang, J.,Zeng, P.,Li, W.,Zhou, X.,Zhang, J.,Wang, Q.,Li, J. Structural Basis for Coronaviral Main Proteases Inhibition by the 3CLpro Inhibitor GC376. J.Mol.Biol., 436:168474-168474, 2024 Cited by PubMed: 38311236DOI: 10.1016/j.jmb.2024.168474 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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