8IG9

Crystal structure of SARS-Cov-2 main protease M49I mutant in complex with GC376

Summary for 8IG9

• Entry DOI: 10.2210/pdb8ig9/pdb
• Descriptor: 3C-like proteinase nsp5, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide (3 entities in total)
• Functional Keywords: viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 2
• Total formula weight: 67072.56

Authors

Zou, X.F.,Zhang, J.,Li, J. (deposition date: 2023-02-20, release date: 2024-03-06, Last modification date: 2024-05-08)

• Primary citation: Lin, C.,Zhu, Z.,Jiang, H.,Zou, X.,Zeng, X.,Wang, J.,Zeng, P.,Li, W.,Zhou, X.,Zhang, J.,Wang, Q.,Li, J.; Structural Basis for Coronaviral Main Proteases Inhibition by the 3CLpro Inhibitor GC376.; J.Mol.Biol., 436:168474-168474, 2024; PubMed: 38311236; DOI: 10.1016/j.jmb.2024.168474

Experimental method

X-RAY DIFFRACTION (1.68 Å)