8I2M

The crystal structure of homodimeric E. coli tryptophanyl-tRNA synthetase bound with niraparib at one of its two active sites

Summary for 8I2M

Entry DOI	10.2210/pdb8i2m/pdb
Descriptor	Tryptophan--tRNA ligase, 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide, SULFATE ION, ... (5 entities in total)
Functional Keywords	tryptophanyl-trna synthetase, fragment screening, antibacterials, ligase
Biological source	Escherichia coli K-12
Total number of polymer chains	2
Total formula weight	77889.48
Authors	Xiang, M.,Zhou, H. (deposition date: 2023-01-14, release date: 2023-04-12, Last modification date: 2024-05-29)
Primary citation	Xiang, M.,Xia, K.,Chen, B.,Luo, Z.,Yu, Y.,Jiang, L.,Zhou, H. An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening. Nucleic Acids Res., 51:4637-4649, 2023 Cited by PubMed: 37070195 DOI: 10.1093/nar/gkad278 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation