8I2L

E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment at the dimerization interface

8I2L の概要

• エントリーDOI: 10.2210/pdb8i2l/pdb
• 分子名称: Tryptophan--tRNA ligase, SULFATE ION, TRYPTOPHANYL-5'AMP, ... (6 entities in total)
• 機能のキーワード: tryptophanyl-trna synthetase, dimer interface, fragment screening, antibacterials, ligase
• 由来する生物種: Escherichia coli K-12
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77608.60

構造登録者

Xiang, M.,Zhou, H. (登録日: 2023-01-14, 公開日: 2023-04-12, 最終更新日: 2024-05-29)

• 主引用文献: Xiang, M.,Xia, K.,Chen, B.,Luo, Z.,Yu, Y.,Jiang, L.,Zhou, H.; An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.; Nucleic Acids Res., 51:4637-4649, 2023; PubMed: 37070195; DOI: 10.1093/nar/gkad278

実験手法

X-RAY DIFFRACTION (1.95 Å)