8HY6
Crystal structure of B1 NDM-1 MBL in complex with 2-amino-5-phenethylthiazole-4-carboxylic acid
Summary for 8HY6
Entry DOI | 10.2210/pdb8hy6/pdb |
Descriptor | Metallo-beta-lactamase type 2, ZINC ION, 2-azanyl-5-(2-phenylethyl)-1,3-thiazole-4-carboxylic acid, ... (5 entities in total) |
Functional Keywords | beta-lactamase class b ndm-1, hydrolase |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 2 |
Total formula weight | 52276.15 |
Authors | |
Primary citation | Yan, Y.H.,Zhang, T.T.,Li, R.,Wang, S.Y.,Wei, L.L.,Wang, X.Y.,Zhu, K.R.,Li, S.R.,Liang, G.Q.,Yang, Z.B.,Yang, L.L.,Qin, S.,Li, G.B. Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding. J.Med.Chem., 66:13746-13767, 2023 Cited by PubMed: 37791640DOI: 10.1021/acs.jmedchem.3c01189 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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