8HXE

Crystal structure of B3 L1 MBL in complex with 2-amino-5-(4-propylbenzyl)thiazole-4-carboxylic acid

Summary for 8HXE

Entry DOI	10.2210/pdb8hxe/pdb
Descriptor	Metallo-beta-lactamase L1 type 3, ZINC ION, 2-azanyl-5-[(4-propylphenyl)methyl]-1,3-thiazole-4-carboxylic acid, ... (5 entities in total)
Functional Keywords	beta-lactamase class b l1, hydrolase
Biological source	Stenotrophomonas maltophilia (Pseudomonas maltophilia, Xanthomonas maltophilia)
Total number of polymer chains	2
Total formula weight	57812.71
Authors	Yan, Y.-H.,Zhu, K.-R.,Li, G.-B. (deposition date: 2023-01-04, release date: 2023-11-01)
Primary citation	Yan, Y.H.,Zhang, T.T.,Li, R.,Wang, S.Y.,Wei, L.L.,Wang, X.Y.,Zhu, K.R.,Li, S.R.,Liang, G.Q.,Yang, Z.B.,Yang, L.L.,Qin, S.,Li, G.B. Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding. J.Med.Chem., 66:13746-13767, 2023 Cited by PubMed: 37791640 DOI: 10.1021/acs.jmedchem.3c01189 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.382 Å)

Structure validation