8HWI

Bacterial STING from Larkinella arboricola in complex with 3'3'-c-di-GMP

Summary for 8HWI

• Entry DOI: 10.2210/pdb8hwi/pdb
• Related: 8HWJ 8HY8 8HY9 8HYN
• Descriptor: CD-NTase-associated protein 12, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one) (3 entities in total)
• Functional Keywords: cd-ntase-associated protein 12, signaling protein
• Biological source: Larkinella arboricola
• Total number of polymer chains: 6
• Total formula weight: 127674.58

Authors

Wang, Y.-C.,Yang, C.-S.,Hou, M.-H.,Chen, Y. (deposition date: 2022-12-30, release date: 2024-01-03, Last modification date: 2024-01-24)

• Primary citation: Hou, M.H.,Wang, Y.C.,Yang, C.S.,Liao, K.F.,Chang, J.W.,Shih, O.,Yeh, Y.Q.,Sriramoju, M.K.,Weng, T.W.,Jeng, U.S.,Hsu, S.D.,Chen, Y.; Structural insights into the regulation, ligand recognition, and oligomerization of bacterial STING.; Nat Commun, 14:8519-8519, 2023; PubMed: 38129386; DOI: 10.1038/s41467-023-44052-x

Experimental method

X-RAY DIFFRACTION (2.73 Å)