8HW4
Cryo-EM structure of dehydroepiandrosterone sulfate-bound human ABC transporter ABCC3 in nanodiscs
Summary for 8HW4
Entry DOI | 10.2210/pdb8hw4/pdb |
EMDB information | 35050 |
Descriptor | ATP-binding cassette sub-family C member 3, 17-oxoandrost-5-en-3beta-yl hydrogen sulfate (2 entities in total) |
Functional Keywords | abc transporter, transport protein, multidrug resistance protein, membrane protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 170241.70 |
Authors | Wang, J.,Wang, F.F.,Chen, Y.X.,Zhou, C.Z. (deposition date: 2022-12-28, release date: 2023-06-07, Last modification date: 2023-10-11) |
Primary citation | Wang, J.,Li, X.,Wang, F.F.,Cheng, M.T.,Mao, Y.X.,Fang, S.C.,Wang, L.,Zhou, C.Z.,Hou, W.T.,Chen, Y. Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket. Embo J., 42:e113415-e113415, 2023 Cited by PubMed: 37485728DOI: 10.15252/embj.2022113415 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.52 Å) |
Structure validation
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