8HVX

Crystal structure of SARS-Cov-2 main protease Y54C mutant in complex with PF07304814

8HVX の概要

• エントリーDOI: 10.2210/pdb8hvx/pdb
• 分子名称: 3C-like proteinase nsp5, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate (3 entities in total)
• 機能のキーワード: viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67282.63

構造登録者

Zhou, X.L.,Zhang, J.,Li, J. (登録日: 2022-12-28, 公開日: 2024-01-17, 最終更新日: 2024-02-07)

• 主引用文献: Jiang, H.,Zou, X.,Zeng, P.,Zeng, X.,Zhou, X.,Wang, J.,Zhang, J.,Li, J.; Crystal structures of main protease (M pro ) mutants of SARS-CoV-2 variants bound to PF-07304814.; Mol Biomed, 4:23-23, 2023; PubMed: 37532968; DOI: 10.1186/s43556-023-00134-2

実験手法

X-RAY DIFFRACTION (1.75 Å)