8HVV

Crystal structure of SARS-Cov-2 main protease S46F mutant in complex with PF07304814

Summary for 8HVV

• Entry DOI: 10.2210/pdb8hvv/pdb
• Descriptor: 3C-like proteinase nsp5, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate (3 entities in total)
• Functional Keywords: viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 2
• Total formula weight: 67522.88

Authors

Zeng, X.Y.,Zhang, J.,Li, J. (deposition date: 2022-12-28, release date: 2024-01-17, Last modification date: 2024-02-07)

• Primary citation: Jiang, H.,Zou, X.,Zeng, P.,Zeng, X.,Zhou, X.,Wang, J.,Zhang, J.,Li, J.; Crystal structures of main protease (M pro ) mutants of SARS-CoV-2 variants bound to PF-07304814.; Mol Biomed, 4:23-23, 2023; PubMed: 37532968; DOI: 10.1186/s43556-023-00134-2

Experimental method

X-RAY DIFFRACTION (1.95 Å)