8HVV
Crystal structure of SARS-Cov-2 main protease S46F mutant in complex with PF07304814
Summary for 8HVV
Entry DOI | 10.2210/pdb8hvv/pdb |
Descriptor | 3C-like proteinase nsp5, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate (3 entities in total) |
Functional Keywords | viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | Severe acute respiratory syndrome coronavirus 2 |
Total number of polymer chains | 2 |
Total formula weight | 67522.88 |
Authors | Zeng, X.Y.,Zhang, J.,Li, J. (deposition date: 2022-12-28, release date: 2024-01-17, Last modification date: 2024-02-07) |
Primary citation | Jiang, H.,Zou, X.,Zeng, P.,Zeng, X.,Zhou, X.,Wang, J.,Zhang, J.,Li, J. Crystal structures of main protease (M pro ) mutants of SARS-CoV-2 variants bound to PF-07304814. Mol Biomed, 4:23-23, 2023 Cited by PubMed: 37532968DOI: 10.1186/s43556-023-00134-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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