8HNY

Crystal structure of cytochrome P450 NasF5053 mutant E73S complexed with 5FCWP

Summary for 8HNY

Entry DOI	10.2210/pdb8hny/pdb
Descriptor	Cytochrome P450-F5053, PROTOPORPHYRIN IX CONTAINING FE, (3~{S},8~{a}~{S})-3-[(4-fluoranyl-1~{H}-indol-3-yl)methyl]-2,3,6,7,8,8~{a}-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, ... (4 entities in total)
Functional Keywords	p450, oxidoreductase
Biological source	Streptomyces sp. NRRL F-5053
Total number of polymer chains	1
Total formula weight	44334.84
Authors	Ma, B.D.,Tian, W.,Qu, X.,Kong, X.D. (deposition date: 2022-12-09, release date: 2023-04-26, Last modification date: 2024-05-29)
Primary citation	Sun, C.,Ma, B.D.,Li, G.,Tian, W.,Yang, L.,Peng, H.,Lin, Z.,Deng, Z.,Kong, X.D.,Qu, X. Engineering the Substrate Specificity of a P450 Dimerase Enables the Collective Biosynthesis of Heterodimeric Tryptophan-Containing Diketopiperazines. Angew.Chem.Int.Ed.Engl., 62:e202304994-e202304994, 2023 Cited by PubMed: 37083030 DOI: 10.1002/anie.202304994 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation