8HNY

Crystal structure of cytochrome P450 NasF5053 mutant E73S complexed with 5FCWP

8HNY の概要

• エントリーDOI: 10.2210/pdb8hny/pdb
• 分子名称: Cytochrome P450-F5053, PROTOPORPHYRIN IX CONTAINING FE, (3~{S},8~{a}~{S})-3-[(4-fluoranyl-1~{H}-indol-3-yl)methyl]-2,3,6,7,8,8~{a}-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, ... (4 entities in total)
• 機能のキーワード: p450, oxidoreductase
• 由来する生物種: Streptomyces sp. NRRL F-5053
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44334.84

構造登録者

Ma, B.D.,Tian, W.,Qu, X.,Kong, X.D. (登録日: 2022-12-09, 公開日: 2023-04-26, 最終更新日: 2024-05-29)

• 主引用文献: Sun, C.,Ma, B.D.,Li, G.,Tian, W.,Yang, L.,Peng, H.,Lin, Z.,Deng, Z.,Kong, X.D.,Qu, X.; Engineering the Substrate Specificity of a P450 Dimerase Enables the Collective Biosynthesis of Heterodimeric Tryptophan-Containing Diketopiperazines.; Angew.Chem.Int.Ed.Engl., 62:e202304994-e202304994, 2023; PubMed: 37083030; DOI: 10.1002/anie.202304994

実験手法

X-RAY DIFFRACTION (2.1 Å)