8HLE

Structure of DddY-DMSOP complex

8HLE の概要

• エントリーDOI: 10.2210/pdb8hle/pdb
• 分子名称: DMSP lyase DddY, ZINC ION, 3-[dimethyl(oxidanyl)-$l^{4}-sulfanyl]propanoic acid, ... (4 entities in total)
• 機能のキーワード: dmsop lyase, complex, lyase
• 由来する生物種: Acinetobacter bereziniae NIPH 3
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 93944.39

構造登録者

Peng, M.,Li, C.Y.,Zhang, Y.Z. (登録日: 2022-11-30, 公開日: 2023-10-04, 最終更新日: 2024-11-20)

主引用文献

Carrion, O.,Li, C.Y.,Peng, M.,Wang, J.,Pohnert, G.,Azizah, M.,Zhu, X.Y.,Curson, A.R.J.,Wang, Q.,Walsham, K.S.,Zhang, X.H.,Monaco, S.,Harvey, J.M.,Chen, X.L.,Gao, C.,Wang, N.,Wang, X.J.,Wang, P.,Giovanonni, S.J.,Lee, C.P.,Suffridge, C.P.,Zhang, Y.,Luo, Z.,Wang, D.,Todd, J.D.,Zhang, Y.Z.
DMSOP-cleaving enzymes are diverse and widely distributed in marine microorganisms.
Nat Microbiol, 8:2326-2337, 2023

PubMed Abstract: Dimethylsulfoxonium propionate (DMSOP) is a recently identified and abundant marine organosulfur compound with roles in oxidative stress protection, global carbon and sulfur cycling and, as shown here, potentially in osmotolerance. Microbial DMSOP cleavage yields dimethyl sulfoxide, a ubiquitous marine metabolite, and acrylate, but the enzymes responsible, and their environmental importance, were unknown. Here we report DMSOP cleavage mechanisms in diverse heterotrophic bacteria, fungi and phototrophic algae not previously known to have this activity, and highlight the unappreciated importance of this process in marine sediment environments. These diverse organisms, including Roseobacter, SAR11 bacteria and Emiliania huxleyi, utilized their dimethylsulfoniopropionate lyase 'Ddd' or 'Alma' enzymes to cleave DMSOP via similar catalytic mechanisms to those for dimethylsulfoniopropionate. Given the annual teragram predictions for DMSOP production and its prevalence in marine sediments, our results highlight that DMSOP cleavage is likely a globally significant process influencing carbon and sulfur fluxes and ecological interactions.

PubMed: 38030907
DOI: 10.1038/s41564-023-01526-4

実験手法

X-RAY DIFFRACTION (1.91 Å)