8HFE

Cryo-EM structure of human norepinephrine transporter NET in an inward-open state at resolution of 2.5 angstrom

Summary for 8HFE

• Entry DOI: 10.2210/pdb8hfe/pdb
• EMDB information: 34718
• Descriptor: Sodium-dependent noradrenaline transporter, CHLORIDE ION (3 entities in total)
• Functional Keywords: norepinephrine transporter, net, slc6a2, norepinephrine, dopamine, neurotransmitter, desipramine, bupropion, antidepressant., transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 69422.00

Authors

Tan, J.,Xiao, Y.,Kong, F.,Lei, J.,Yuan, Y.,Yan, C. (deposition date: 2022-11-10, release date: 2024-05-15, Last modification date: 2024-08-07)

• Primary citation: Tan, J.,Xiao, Y.,Kong, F.,Zhang, X.,Xu, H.,Zhu, A.,Liu, Y.,Lei, J.,Tian, B.,Yuan, Y.,Yan, C.; Molecular basis of human noradrenaline transporter reuptake and inhibition.; Nature, 2024; PubMed: 39048818; DOI: 10.1038/s41586-024-07719-z

Experimental method