8HAD

A novel dimer configuration of a diatom Get3 forming a tetrameric complex with its tail-anchored membrane cargo

8HAD の概要

• エントリーDOI: 10.2210/pdb8had/pdb
• 分子名称: ATPase ASNA1 homolog (1 entity in total)
• 機能のキーワード: get3, arsa2, arsa1, trc40, tail-anchored, post-translational pathway, diatom, chaperone
• 由来する生物種: Phaeodactylum tricornutum CCAP 1055/1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77673.89

構造登録者

Chang, H.Y.,Ko, T.P. (登録日: 2022-10-26, 公開日: 2024-05-15, 最終更新日: 2024-06-26)

主引用文献

Chen, C.C.,Huang, Y.R.,Chan, Y.T.,Lin, H.Y.,Lin, H.J.,Hsiao, C.D.,Ko, T.P.,Lin, T.W.,Lan, Y.H.,Lin, H.Y.,Chang, H.Y.
A distinct dimer configuration of a diatom Get3 forming a tetrameric complex with its tail-anchored membrane cargo.
Bmc Biol., 22:136-136, 2024

PubMed Abstract: Most tail-anchored (TA) membrane proteins are delivered to the endoplasmic reticulum through a conserved posttranslational pathway. Although core mechanisms underlying the targeting and insertion of TA proteins are well established in eukaryotes, their role in mediating TA protein biogenesis in plants remains unclear. We reported the crystal structures of algal arsenite transporter 1 (ArsA1), which possesses an approximately 80-kDa monomeric architecture and carries chloroplast-localized TA proteins. However, the mechanistic basis of ArsA2, a Get3 (guided entry of TA proteins 3) homolog in plants, for TA recognition remains unknown.

PubMed: 38867239
DOI: 10.1186/s12915-024-01933-x

実験手法

X-RAY DIFFRACTION (3.81 Å)