8H70

Crystal structure of the catalytic ATP-binding domain of the PhoR sensor histidine kinase from Vibrio cholera

8H70 の概要

• エントリーDOI: 10.2210/pdb8h70/pdb
• 分子名称: Phosphate regulon sensor protein PhoR, DI(HYDROXYETHYL)ETHER (3 entities in total)
• 機能のキーワード: histidine kinase, membrane protein
• 由来する生物種: Vibrio cholerae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18332.92

構造登録者

Jia, R.,Zhao, W.,Hattori, M. (登録日: 2022-10-18, 公開日: 2023-02-15, 最終更新日: 2024-05-29)

主引用文献

Jia, R.,Zhao, Y.,Hattori, M.
Crystal structure of the catalytic ATP-binding domain of the PhoR sensor histidine kinase.
Proteins, 91:999-1004, 2023

PubMed Abstract: The two-component regulatory system (TCS) is a major regulatory system in bacteria that occurs in response to environmental changes and involves the sensor histidine kinase (HK) protein and response regulator (RR) protein. Among the TCSs, PhoR/PhoB is crucial for bacteria to adapt to changes in environmental phosphate concentrations. In addition, recent studies have shown that PhoR binding to the MgtC virulence factor activates phosphate transport for normal pathogenesis. In this work, we determined the crystal structure of the catalytic ATP binding domain of the PhoR sensor histidine kinase from Vibrio cholera, compared the structure with the known HK protein structures and discussed the potential binding interface with MgtC.

PubMed: 36732678
DOI: 10.1002/prot.26473

実験手法

X-RAY DIFFRACTION (1.88 Å)