8GWI

A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors

8GWI の概要

• エントリーDOI: 10.2210/pdb8gwi/pdb
• EMDBエントリー: 34313
• 分子名称: RNA-directed RNA polymerase, Non-structural protein 8, Non-structural protein 7, ... (10 entities in total)
• 機能のキーワード: sars-cov-2, capping, nucleotide analogue inhibitor, cryo-em, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 325750.70

構造登録者

Yan, L.M.,Huang, Y.C.,Ge, J.,Liu, Z.Y.,Gao, Y.,Rao, Z.H.,Lou, Z.Y. (登録日: 2022-09-17, 公開日: 2022-12-14, 最終更新日: 2024-07-03)

• 主引用文献: Yan, L.,Huang, Y.,Ge, J.,Liu, Z.,Lu, P.,Huang, B.,Gao, S.,Wang, J.,Tan, L.,Ye, S.,Yu, F.,Lan, W.,Xu, S.,Zhou, F.,Shi, L.,Guddat, L.W.,Gao, Y.,Rao, Z.,Lou, Z.; A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors.; Cell, 185:4347-4360.e17, 2022; PubMed: 36335936; DOI: 10.1016/j.cell.2022.09.037

実験手法

ELECTRON MICROSCOPY (3.18 Å)