8GVL
PTPN21 FERM
Summary for 8GVL
Entry DOI | 10.2210/pdb8gvl/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 21, (4S)-2-METHYL-2,4-PENTANEDIOL (3 entities in total) |
Functional Keywords | ptpn21, phosphotase, ferm, protein binding |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 70567.94 |
Authors | Chen, L.,Zheng, Y.Y.,Zhou, C. (deposition date: 2022-09-15, release date: 2023-09-20, Last modification date: 2024-04-17) |
Primary citation | Chen, L.,Qian, Z.,Zheng, Y.,Zhang, J.,Sun, J.,Zhou, C.,Xiao, H. Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10:eadi7404-eadi7404, 2024 Cited by PubMed: 38416831DOI: 10.1126/sciadv.adi7404 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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