8GUB

Cryo-EM structure of cancer-specific PI3Kalpha mutant H1047R in complex with BYL-719

8GUB の概要

• エントリーDOI: 10.2210/pdb8gub/pdb
• EMDBエントリー: 34272
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide (3 entities in total)
• 機能のキーワード: phosphoinositide 3-kinase (pi3k), kinase domain, mutation, cancers, structural protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 211906.30

構造登録者

Liu, X.,Zhou, Q.,Hart, J.R.,Xu, Y.,Yang, S.,Yang, D.,Vogt, P.K.,Wang, M.-W. (登録日: 2022-09-11, 公開日: 2022-11-23, 最終更新日: 2024-07-03)

• 主引用文献: Liu, X.,Zhou, Q.,Hart, J.R.,Xu, Y.,Yang, S.,Yang, D.,Vogt, P.K.,Wang, M.W.; Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha.; Proc.Natl.Acad.Sci.USA, 119:e2215621119-e2215621119, 2022; PubMed: 36343266; DOI: 10.1073/pnas.2215621119

実験手法

ELECTRON MICROSCOPY (2.73 Å)