8GUA
Cryo-EM structure of cancer-specific PI3Kalpha mutant E542K in complex with BYL-719
Summary for 8GUA
Entry DOI | 10.2210/pdb8gua/pdb |
EMDB information | 34271 |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide (2 entities in total) |
Functional Keywords | phosphoinositide 3-kinase (pi3k), helical domain, mutation, cancers, structural protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 128264.11 |
Authors | Liu, X.,Zhou, Q.,Hart, J.R.,Xu, Y.,Yang, S.,Yang, D.,Vogt, P.K.,Wang, M.-W. (deposition date: 2022-09-11, release date: 2022-12-07, Last modification date: 2024-07-03) |
Primary citation | Liu, X.,Zhou, Q.,Hart, J.R.,Xu, Y.,Yang, S.,Yang, D.,Vogt, P.K.,Wang, M.W. Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha. Proc.Natl.Acad.Sci.USA, 119:e2215621119-e2215621119, 2022 Cited by PubMed: 36343266DOI: 10.1073/pnas.2215621119 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.77 Å) |
Structure validation
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