8GKY

Human mitochondrial serine hydroxymethyltransferase (SHMT2) Y105F in complex with PLP, glycine and AGF359 inhibitor

8GKY の概要

• エントリーDOI: 10.2210/pdb8gky/pdb
• 分子名称: Serine hydroxymethyltransferase, mitochondrial, N-{4-[3-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)propyl]-2-fluorobenzoyl}-L-glutamic acid, GLYCINE, ... (5 entities in total)
• 機能のキーワード: shmt2 mutant, tetramer, glycine synthesis, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 110743.13

構造登録者

Katinas, J.M.,Dann III, C.E. (登録日: 2023-03-20, 公開日: 2024-03-20)

• 主引用文献: Katinas, J.M.,Nayeen, M.J.,Schneider, M.,Shah, K.,Fifer, A.N.,Klapper, L.M.,Sharma, A.,Thalluri, K.,Van Nieuwenhze, M.S.,Hou, Z.,Gangjee, A.,Matherly, L.H.,Dann 3rd, C.E.; Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.; Biochemistry, 2024; PubMed: 38324671; DOI: 10.1021/acs.biochem.3c00613

実験手法

X-RAY DIFFRACTION (2.77 Å)