8GF7
Cryo-EM structure of serine 87 O-GlcNAc-modified alpha-synuclein fibrils
Summary for 8GF7
| Entry DOI | 10.2210/pdb8gf7/pdb |
| EMDB information | 29980 |
| Descriptor | Alpha-synuclein, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total) |
| Functional Keywords | alpha-synuclein, o-glcnac, amyloid, fibril, posttranslational modification, protein fibril |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 6 |
| Total formula weight | 54013.28 |
| Authors | Balana, J.A.,Nguyen, A.B.,Saelices, L.,Pratt, R.M. (deposition date: 2023-03-07, release date: 2023-11-08, Last modification date: 2024-05-15) |
| Primary citation | Balana, A.T.,Mahul-Mellier, A.L.,Nguyen, B.A.,Horvath, M.,Javed, A.,Hard, E.R.,Jasiqi, Y.,Singh, P.,Afrin, S.,Pedretti, R.,Singh, V.,Lee, V.M.,Luk, K.C.,Saelices, L.,Lashuel, H.A.,Pratt, M.R. O-GlcNAc forces an alpha-synuclein amyloid strain with notably diminished seeding and pathology. Nat.Chem.Biol., 20:646-655, 2024 Cited by PubMed: 38347213DOI: 10.1038/s41589-024-01551-2 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (4.8 Å) |
Structure validation
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