8GEM

Crystal structure of human cellular retinol binding protein 1 in complex with N-ethyl-N-({3-[1-(4-methylphenyl)cyclopentyl]-1,2,4-oxadiazol-5-yl}methyl)-2-(1H-pyrazol-1-yl)ethanamine

8GEM の概要

• エントリーDOI: 10.2210/pdb8gem/pdb
• 分子名称: Retinol-binding protein 1, N-ethyl-N-({3-[1-(4-methylphenyl)cyclopentyl]-1,2,4-oxadiazol-5-yl}methyl)-2-(1H-pyrazol-1-yl)ethan-1-amine (3 entities in total)
• 機能のキーワード: rbp1, crbp1, retinol-binding, retinol, vitamin a, retinol-binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17079.56

構造登録者

Plau, J.,Golczak, M. (登録日: 2023-03-07, 公開日: 2023-10-04, 最終更新日: 2023-11-01)

• 主引用文献: Plau, J.,Morgan, C.E.,Fedorov, Y.,Banerjee, S.,Adams, D.J.,Blaner, W.S.,Yu, E.W.,Golczak, M.; Discovery of Nonretinoid Inhibitors of CRBP1: Structural and Dynamic Insights for Ligand-Binding Mechanisms.; Acs Chem.Biol., 18:2309-2323, 2023; PubMed: 37713257; DOI: 10.1021/acschembio.3c00402

実験手法

X-RAY DIFFRACTION (1.55 Å)