8GA2

Bromodomain of CBP liganded with inhibitor iCBP5

8GA2 の概要

• エントリーDOI: 10.2210/pdb8ga2/pdb
• 分子名称: CREB-binding protein, 1,2-ETHANEDIOL, (6S)-6-{(5M)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1s,4R)-4-methoxycyclohexyl]-1H-benzimidazol-2-yl}-1-phenylpiperidin-2-one, ... (4 entities in total)
• 機能のキーワード: bromodomain, complex, transcription, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 57448.06

構造登録者

Schonbrunn, E.,Bikowitz, M. (登録日: 2023-02-22, 公開日: 2024-02-28, 最終更新日: 2024-05-08)

• 主引用文献: Shendy, N.A.M.,Bikowitz, M.,Sigua, L.H.,Zhang, Y.,Mercier, A.,Khashana, Y.,Nance, S.,Liu, Q.,Delahunty, I.M.,Robinson, S.,Goel, V.,Rees, M.G.,Ronan, M.A.,Wang, T.,Kocak, M.,Roth, J.A.,Wang, Y.,Freeman, B.B.,Orr, B.A.,Abraham, B.J.,Roussel, M.F.,Schonbrunn, E.,Qi, J.,Durbin, A.D.; Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition.; Nat Commun, 15:3483-3483, 2024; PubMed: 38664416; DOI: 10.1038/s41467-024-47102-0

実験手法

X-RAY DIFFRACTION (1.85 Å)