8G8N

CTLA4 Fab with peptide

8G8N の概要

• エントリーDOI: 10.2210/pdb8g8n/pdb
• 分子名称: Fab heavy chain, Fab light chain, CYS-PRO-GLY-LYS-GLY-LEU-PRO-SER-CYS (3 entities in total)
• 機能のキーワード: anti-ctla4 mab, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 18
• 化学式量合計: 289156.69

構造登録者

Williams, J.C. (登録日: 2023-02-18, 公開日: 2024-01-17)

• 主引用文献: Jenkins, K.A.,Park, M.,Pederzoli-Ribeil, M.,Eskiocak, U.,Johnson, P.,Guzman, W.,McLaughlin, M.,Moore-Lai, D.,O'Toole, C.,Liu, Z.,Nicholson, B.,Flesch, V.,Qiu, H.,Clackson, T.,O'Hagan, R.C.,Rodeck, U.,Karow, M.,O'Neil, J.,Williams, J.C.; XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer.; J Immunother Cancer, 11:-, 2023; PubMed: 38164757; DOI: 10.1136/jitc-2023-007785

実験手法

X-RAY DIFFRACTION (3 Å)