8G8D

Crystal structure of DH1346 Fab in complex with HIV proximal MPER peptide

Summary for 8G8D

• Entry DOI: 10.2210/pdb8g8d/pdb
• Related: 8G8A 8G8C
• Descriptor: DH1346 heavy chain, DH1346 light chain, gp41 MPER peptide, ... (6 entities in total)
• Functional Keywords: hiv, neutralizing antibody, mper, gp41, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 104861.61

Authors

Niyongabo, A.,Janus, B.M.,Ofek, G. (deposition date: 2023-02-17, release date: 2024-05-22, Last modification date: 2024-06-19)

• Primary citation: Williams, W.B.,Alam, S.M.,Ofek, G.,Erdmann, N.,Montefiori, D.C.,Seaman, M.S.,Wagh, K.,Korber, B.,Edwards, R.J.,Mansouri, K.,Eaton, A.,Cain, D.W.,Martin, M.,Hwang, J.,Arus-Altuz, A.,Lu, X.,Cai, F.,Jamieson, N.,Parks, R.,Barr, M.,Foulger, A.,Anasti, K.,Patel, P.,Sammour, S.,Parsons, R.J.,Huang, X.,Lindenberger, J.,Fetics, S.,Janowska, K.,Niyongabo, A.,Janus, B.M.,Astavans, A.,Fox, C.B.,Mohanty, I.,Evangelous, T.,Chen, Y.,Berry, M.,Kirshner, H.,Van Itallie, E.,Saunders, K.O.,Wiehe, K.,Cohen, K.W.,McElrath, M.J.,Corey, L.,Acharya, P.,Walsh, S.R.,Baden, L.R.,Haynes, B.F.; Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans.; Cell, 187:2919-2934.e20, 2024; PubMed: 38761800; DOI: 10.1016/j.cell.2024.04.033

Experimental method

X-RAY DIFFRACTION (2.02 Å)