8G63

Ralimetinib (LY2228820) in complex with wild type EGFR

Summary for 8G63

Entry DOI	10.2210/pdb8g63/pdb
Descriptor	Epidermal growth factor receptor, ralimetinib (3 entities in total)
Functional Keywords	kinase inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	37724.65
Authors	Chitnis, S.P.,Heppner, D.E. (deposition date: 2023-02-14, release date: 2023-10-11, Last modification date: 2024-04-24)
Primary citation	Bhattacharjee, D.,Bakar, J.,Chitnis, S.P.,Sausville, E.L.,Ashtekar, K.D.,Mendelson, B.E.,Long, K.,Smith, J.C.,Heppner, D.E.,Sheltzer, J.M. Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor. Cell Chem Biol, 30:1211-1222.e5, 2023 Cited by PubMed: 37827156 DOI: 10.1016/j.chembiol.2023.09.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation