8G5M

Cryo-EM structure of the Mismatch Locking Complex (III) of Human Mitochondrial DNA Polymerase Gamma

Summary for 8G5M

• Entry DOI: 10.2210/pdb8g5m/pdb
• EMDB information: 29749
• Descriptor: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, Mismatched RNA Primer, ... (4 entities in total)
• Functional Keywords: mitochondrial dna polymerase, dna proofreading, mismatch locking, replication-dna-rna complex, replication/dna/rna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 266645.31

Authors

Nayak, A.R.,Buchel, G.,Herbine, K.H.,Sarfallah, A.,Sokolova, V.O.,Zamudio-Ochoa, A.,Temiakov, D. (deposition date: 2023-02-13, release date: 2024-01-10)

• Primary citation: Buchel, G.,Nayak, A.R.,Herbine, K.,Sarfallah, A.,Sokolova, V.O.,Zamudio-Ochoa, A.,Temiakov, D.; Structural basis for DNA proofreading.; Nat Commun, 14:8501-8501, 2023; PubMed: 38151585; DOI: 10.1038/s41467-023-44198-8

Experimental method

ELECTRON MICROSCOPY (2.58 Å)