8G50
E. coli DHFR complex with NADP+ and folate: EF-X excited state model by Laue diffraction (electric field along b axis; 8-fold extrapolation of structure factor differences)
Summary for 8G50
| Entry DOI | 10.2210/pdb8g50/pdb |
| Descriptor | Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
| Functional Keywords | dihydrofolate reductase, oxidoreductase |
| Biological source | Escherichia coli |
| Total number of polymer chains | 2 |
| Total formula weight | 39021.66 |
| Authors | Greisman, J.B.,Dalton, K.M.,Brookner, D.E.,Klureza, M.A.,Hekstra, D.R. (deposition date: 2023-02-10, release date: 2024-01-03, Last modification date: 2024-07-24) |
| Primary citation | Greisman, J.B.,Dalton, K.M.,Brookner, D.E.,Klureza, M.A.,Sheehan, C.J.,Kim, I.S.,Henning, R.W.,Russi, S.,Hekstra, D.R. Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121:e2313192121-e2313192121, 2024 Cited by PubMed: 38386706DOI: 10.1073/pnas.2313192121 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
Download full validation report
