8G50

E. coli DHFR complex with NADP+ and folate: EF-X excited state model by Laue diffraction (electric field along b axis; 8-fold extrapolation of structure factor differences)

8G50 の概要

• エントリーDOI: 10.2210/pdb8g50/pdb
• 分子名称: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: dihydrofolate reductase, oxidoreductase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 39021.66

構造登録者

Greisman, J.B.,Dalton, K.M.,Brookner, D.E.,Klureza, M.A.,Hekstra, D.R. (登録日: 2023-02-10, 公開日: 2024-01-03, 最終更新日: 2024-07-24)

• 主引用文献: Greisman, J.B.,Dalton, K.M.,Brookner, D.E.,Klureza, M.A.,Sheehan, C.J.,Kim, I.S.,Henning, R.W.,Russi, S.,Hekstra, D.R.; Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.; Proc.Natl.Acad.Sci.USA, 121:e2313192121-e2313192121, 2024; PubMed: 38386706; DOI: 10.1073/pnas.2313192121

実験手法

X-RAY DIFFRACTION (1.7 Å)