8G3Y

MBP-Mcl1 in complex with ligand 34

8G3Y の概要

• エントリーDOI: 10.2210/pdb8g3y/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900001
• 分子名称: Maltodextrin-binding protein, Induced myeloid leukemia cell differentiation protein Mcl-1 chimera, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, CHLORIDE ION, ... (7 entities in total)
• 機能のキーワード: myeloid cell leukemia 1, mcl-1, b-cell lymphoma 2, bcl-2, bh3 mimetic, protein-protein interaction, modulator, apoptosis, cancer, leukemia, myeloma, lymphoma, physicochemical properties, adme properties, cardiotoxicity, therapeutic window
• 由来する生物種: Serratia sp. (strain FS14); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 58940.93

構造登録者

Miller, B.R.,Shaffer, P. (登録日: 2023-02-08, 公開日: 2023-05-17, 最終更新日: 2023-05-24)

• 主引用文献: Romanov-Michailidis, F.,Hsiao, C.C.,Urner, L.M.,Jerhaoui, S.,Surkyn, M.,Miller, B.,Vos, A.,Dominguez Blanco, M.,Bueters, R.,Vinken, P.,Bekkers, M.,Walker, D.,Pietrak, B.,Eyckmans, W.,Dores-Sousa, J.L.,Joo Koo, S.,Lento, W.,Bauser, M.,Philippar, U.,Rombouts, F.J.R.; Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies.; J.Med.Chem., 66:6122-6148, 2023; PubMed: 37114951; DOI: 10.1021/acs.jmedchem.2c01953

実験手法

X-RAY DIFFRACTION (1.7 Å)