8G2R
CRYSTAL STRUCTURE OF THE KPC-2 D179N VARIANT IN COMPLEX WITH AVIBACTAM
Summary for 8G2R
Entry DOI | 10.2210/pdb8g2r/pdb |
Descriptor | Carbapenem-hydrolyzing beta-lactamase KPC, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide (3 entities in total) |
Functional Keywords | beta-lactamase, inhibitor, antibiotic resistance, hydrolase, hydrolase-antibiotic complex, hydrolase/antibiotic |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 28443.01 |
Authors | Alsenani, T.,van den Akker, F. (deposition date: 2023-02-06, release date: 2023-08-09, Last modification date: 2023-11-01) |
Primary citation | Alsenani, T.A.,Viviani, S.L.,Papp-Wallace, K.M.,Bonomo, R.A.,van den Akker, F. Exploring avibactam and relebactam inhibition of Klebsiella pneumoniae carbapenemase D179N variant: role of the Omega loop-held deacylation water. Antimicrob.Agents Chemother., 67:e0035023-e0035023, 2023 Cited by PubMed: 37750722DOI: 10.1128/aac.00350-23 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.28 Å) |
Structure validation
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