8G10
Structure of Ternary Complex of cGAS with dsDNA and Bound ITP and GTP
Summary for 8G10
Entry DOI | 10.2210/pdb8g10/pdb |
Descriptor | Cyclic GMP-AMP synthase, Palindromic DNA18, GUANOSINE-5'-TRIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | immune system/dna, transferase-dna complex, transferase/dna |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 6 |
Total formula weight | 109607.12 |
Authors | |
Primary citation | Wu, S.,Gabelli, S.B.,Sohn, J. The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS. Nat Commun, 15:4012-4012, 2024 Cited by PubMed: 38740774DOI: 10.1038/s41467-024-48365-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.47 Å) |
Structure validation
Download full validation report