8FWY

Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to the dead-end complex xanthine and pyrophosphate

8FWY の概要

• エントリーDOI: 10.2210/pdb8fwy/pdb
• 分子名称: Hypoxanthine-guanine phosphoribosyltransferase, XANTHINE, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: hypoxanthine-guanine-xanthine phosphoribosyltransferase, hgxprt, transferase
• 由来する生物種: Trypanosoma cruzi (strain CL Brener)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 52260.13

構造登録者

Hughes, R.,Meneely, K.M.,Glockzin, K.,Tyler, P.C.,Lamb, A.L.,Meek, T.D.,Katzfuss, A. (登録日: 2023-01-23, 公開日: 2023-07-19, 最終更新日: 2023-11-22)

• 主引用文献: Glockzin, K.,Meneely, K.M.,Hughes, R.,Maatouk, S.W.,Pina, G.E.,Suthagar, K.,Clinch, K.,Buckler, J.N.,Lamb, A.L.,Tyler, P.C.,Meek, T.D.,Katzfuss, A.; Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors.; Biochemistry, 62:2182-2201, 2023; PubMed: 37418678; DOI: 10.1021/acs.biochem.3c00116

実験手法

X-RAY DIFFRACTION (1.54 Å)