8FWS
Structure of the ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344
8FWS の概要
エントリーDOI | 10.2210/pdb8fws/pdb |
EMDBエントリー | 29517 |
分子名称 | Glutamate receptor ionotropic, kainate 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
機能のキーワード | ion channel, iglur, kainate receptor, positive allosteric modulator, membrane protein |
由来する生物種 | Rattus norvegicus (Norway rat) |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 427016.43 |
構造登録者 | |
主引用文献 | Gangwar, S.P.,Yen, L.Y.,Yelshanskaya, M.V.,Sobolevsky, A.I. Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel. Cell Rep, 42:112124-112124, 2023 Cited by PubMed: 36857176DOI: 10.1016/j.celrep.2023.112124 主引用文献が同じPDBエントリー |
実験手法 | ELECTRON MICROSCOPY (3.23 Å) |
構造検証レポート
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