8FTB

Crystal structure of integrin beta-2 tail bound to the FERM-folded talin head domain with a K306Q mutation

Summary for 8FTB

• Entry DOI: 10.2210/pdb8ftb/pdb
• Descriptor: Integrin beta-2,Talin-1 (2 entities in total)
• Functional Keywords: integrin, beta-2, talin, ferm, complex, k306q, cell adhesion
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 1
• Total formula weight: 47405.41

Authors

Wu, J.,Gao, T. (deposition date: 2023-01-11, release date: 2024-07-03, Last modification date: 2025-05-07)

• Primary citation: Gao, T.,Maskalenko, N.A.,Kabir, S.,Campbell, K.S.,Wu, J.; Molecular basis of beta 2 integrin activation by talin unveils subunit-specific mechanisms of integrin signaling; Cell Rep, 44:115607-, 2025; DOI: 10.1016/j.celrep.2025.115607

Experimental method

X-RAY DIFFRACTION (1.97 Å)