8FS2

CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor 11b (YD907)

8FS2 の概要

• エントリーDOI: 10.2210/pdb8fs2/pdb
• 分子名称: Site-specific DNA-methyltransferase (adenine-specific), DNA (5'-D(*TP*TP*CP*AP*AP*AP*AP*AP*GP*TP*CP*CP*CP*A)-3'), 1,2-ETHANEDIOL, ... (7 entities in total)
• 機能のキーワード: dna adenine methylation, protein-dna complex, transferase, dna binding protein, transferase-dna-inhibitor complex, transferase/dna/inhibitor
• 由来する生物種: Clostridioides difficile; 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 234499.65

構造登録者

Zhou, J.,Horton, J.R.,Cheng, X. (登録日: 2023-01-09, 公開日: 2023-05-10, 最終更新日: 2024-05-22)

• 主引用文献: Zhou, J.,Deng, Y.,Iyamu, I.D.,Horton, J.R.,Yu, D.,Hajian, T.,Vedadi, M.,Rotili, D.,Mai, A.,Blumenthal, R.M.,Zhang, X.,Huang, R.,Cheng, X.; Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile- Specific DNA Adenine Methyltransferase.; Acs Chem.Biol., 18:734-745, 2023; PubMed: 37082867; DOI: 10.1021/acschembio.3c00035

実験手法

X-RAY DIFFRACTION (2.59 Å)