8FQJ
LSD1-CoREST in complex with T14, short soaking
Summary for 8FQJ
| Entry DOI | 10.2210/pdb8fqj/pdb |
| Descriptor | Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2S,3R,4R)-2,3,4-trihydroxy-5-[(1R,3S,3aS,13R)-1-hydroxy-10,11-dimethyl-3-{4-[(5-methyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenyl}-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]pentyl dihydrogen diphosphate (3 entities in total) |
| Functional Keywords | epigenetics, histone demethylase, drug resistance, covalent inhibitor, oxidoreductase |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 112572.25 |
| Authors | |
| Primary citation | Caroli, J.,Mattevi, A. Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 To be published, |
| Experimental method |
Structure validation
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