8FO5

Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 1-(1-(phenylsulfonyl)-1H-pyrrol-3-yl)ethan-1-one

Summary for 8FO5

Entry DOI	10.2210/pdb8fo5/pdb
Descriptor	H9 immunoglobulin light chain, 1-[1-(benzenesulfonyl)-1H-pyrrol-3-yl]ethan-1-one, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	light chain, amyloidosis, stabilizer, immune system
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	91077.09
Authors	Yan, N.L.,Wilson, I.A.,Kelly, J.W. (deposition date: 2022-12-29, release date: 2023-05-24, Last modification date: 2023-10-25)
Primary citation	Yan, N.L.,Wilson, I.A.,Kelly, J.W. Crystal Structures of Diaryl Hydrazone and Sulfone Stabilizers in Complex with an Amyloidogenic Light Chain Reveal an Alternate Ligand-Binding Cavity Isr.J.Chem., 2023 Cited by DOI: 10.1002/ijch.202300002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation