8FO4

Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 6-methyl-2-(2-((1E,2E)-3-(2-nitrophenyl)allylidene)hydrazineyl)pyrimidin-4-ol

8FO4 の概要

• エントリーDOI: 10.2210/pdb8fo4/pdb
• 分子名称: H9 immunoglobulin light chain, 6-methyl-2-{2-[(1E)-3-(2-nitrophenyl)prop-1-en-1-yl]hydrazinyl}pyrimidin-4(5H)-one, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: light chain, amyloidosis, stabilizer, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 90991.18

構造登録者

Yan, N.L.,Wilson, I.A.,Kelly, J.W. (登録日: 2022-12-29, 公開日: 2023-05-24, 最終更新日: 2024-10-23)

• 主引用文献: Yan, N.L.,Wilson, I.A.,Kelly, J.W.; Crystal Structures of Diaryl Hydrazone and Sulfone Stabilizers in Complex with an Amyloidogenic Light Chain Reveal an Alternate Ligand-Binding Cavity; Isr.J.Chem., 2023; DOI: 10.1002/ijch.202300002

実験手法

X-RAY DIFFRACTION (2 Å)